Messi, 23, won the prize - a merger of the Fifa Player of the Year prize and Ballon d'Or - ahead of his Barca team-mates Andres Iniesta and Xavi.
"I'm surprised to win but pleased to be here with my friends," said Messi, who won the two separate awards last year.
Jose Mourinho, who won an unprecedented Treble with Inter Milan in 2010, was named the Coach of the Year.
Source: BBC Sports
